PAI-1 mutation
The LAMP Human PAI-1 mutation KIT is an in vitro diagnostic test intended for the qualitative detection of PAI-1 insertion/deletion (5G/4G) by Loop-mediated isothermal amplification (LAMP) on EDTA whole blood and extracted DNA. This assay is dedicated to professional use in diagnostic laboratories. The device is not for self-testing.
A common single nucleotide insertion/deletion (5G/4G) in the promotor region of the plasminogen activator inhibitor-1 (PAI-1) gene results in higher levels of PAI-1 in the serum. Since PAI-1 indirectly inhibits the breakdown of blood clots, heterozygous or homozygous carriers of this mutation have an increased risk of venous thrombosis, particularly when other relevant thrombosis-related mutations are present simultaneously.
Format: 24 or 96 determinations
Storage: At -20°C. 8 freeze and thaw max.
Possible automation: Yes
Analysis software : Yes
Turn around time: Around 1 hour
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