Detection of the 4G/5G Plasminogen Activator Inhibitor-1 mutation.
The LAMP Human PAI-1 mutation KIT is an in vitro diagnostic test. This assay is dedicated to professional use in diagnostic laboratory. The device is not for self-testing.
Plasminogen activator inhibitor-1 (PAI-1) belongs to the serine protease superfamily. It is a primary regulator of plasminogen activation. A common single nucleotide insertion/deletion in the promotor region of the PAI-1 gene has been identified and is related to circulation PAI-1 concentrations, whereby the 4G allele shows highest PAI-1 concentrations.
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