TPMT
The LAMP Human TPMT deficiency KIT is an in vitro diagnostic test intended for the qualitative detection of three different TPMT alleles (*3B, *3C, *2) by Loop-mediated isothermal amplification (LAMP) on EDTA whole blood and extracted DNA. This assay is dedicated to professional use in diagnostic laboratories. The device is not for self-testing.
The enzyme thiopurine S-methyltransferase (TPMT) plays a key role in metabolizing thiopurine drugs, which are used to treat various cancers and immune disorders, as well as to prevent organ transplant rejection. Genetic mutations on the TPMT gene lead to unstable proteins, resulting in low enzyme activity. Individuals with reduced or absent TPMT activity at very high risk of life-threatening myelosuppression.
Genotyping tests target three TPMT variants - *3B, *3C, and *2 - that account for over 90% of low activity phenotypes and are the most common inactivating alleles.
The genotyping of TPMT is complementary to the identification of the NUDT15 risk allele: the latter is the main genetic cause of thiopurine intolerance in Asian, while TPMT deficiency is most common among in Europeans and Africans.
Source : https://files.cpicpgx.org/data/guideline/publication/thiopurines/2018/30447069.pdf
Format: 24 determinations
Storage: At -20°C. 8 freeze and thaw max.
Possible automation: Yes
Analysis software : Yes
Turn around time: Around 1 hour
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