NUDT15
The LAMP Human NUDT15 deficiency KIT is an in vitro diagnostic test intended for the qualitative detection of three different NUDT15 alleles (*3, *6, 9*) by Loop-mediated isothermal amplification (LAMP) on EDTA whole blood and extracted DNA. This assay is dedicated to professional use in diagnostic laboratories. The device is not for self-testing.
NUDIX hydrolase 15 (NUDT15) is an enzyme directly involved in the metabolism of thiopurines, a class of immunosuppressive drugs, used for the treatment of several forms of cancer, immune system disorders and the prevention of rejection after organ transplantation. Individuals with reduced or absent NUDT15 activity have a higher sensitivity to thiopurines at standard doses and are at a higher risk of toxic side effects.
The genotyping of NUDT15 is complementary to the identification of the TPMT risk allele: the latter is the main genetic cause of thiopurine intolerance in Europeans and Africans, while NUDT15 deficiency is most common among in Asians.
Source : https://files.cpicpgx.org/data/guideline/publication/thiopurines/2018/30447069.pdf
Format: 24 determinations
Storage: At -20°C. 8 freeze and thaw max.
Possible automation: Yes
Analysis software : Yes
Turn around time: Around 1 hour
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