CYP2C9
The LAMP Human CYP2C9 deficiency KIT is an in vitro diagnostic test intended for the qualitative detection of two less functional CYP2C9 alleles (*2, *3) by Loop-mediated isothermal amplification (LAMP) on EDTA whole blood and extracted DNA. This assay is dedicated to professional use in diagnostic laboratories. The device is not for self-testing.
The CYP2C9 enzyme plays an important role in the metabolism of many drugs including anticonvulsants, hypoglycemic drugs, anti-hypertensives, anti-inflammatories, and anticoagulants, among others. Genetic mutations on the CYP2C9 gene are known to decrease the enzyme’s activity. Individuals carrying CYP2C9 variants are at risk of adverse drug reactions or may present a lack of response to treatment.
The most common CYP2C9 variants responsible for a reduction of the enzyme’s activity are *2 (rs1799853, 430C>T or R144C) and *3 (rs1057910, 1075A>C or I359L).
Format: 24 determinations
Storage: At -20°C. 8 freeze and thaw max.
Possible automation: Yes
Analysis software : Yes
Turn around time: Around 1 hour
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