CYP2C19
The LAMP Human CYP2C19 deficiency KIT is an in vitro diagnostic test intended for the qualitative detection of three less functional CYP2C19 alleles (*2, *3, *17) by Loop-mediated isothermal amplification (LAMP) on EDTA whole blood and extracted DNA. This assay is dedicated to professional use in diagnostic laboratories. The device is not for self-testing.
The CYP2C19 enzyme plays a role in the metabolism of at least 10% of commonly prescribed drugs, including antidepressants and a very used antiplatelet drug.
CYP2C19 catalyzes the bioactivation of this antiplatelet drug, and CYP2C19 genotype influences its conversion into active metabolite. Individuals carrying CYP2C19 variants and who receive this drug are at risk of reduced platelet inhibition and major adverse cardiovascular and cerebrovascular events [1].
The two most common CYP2C19 gene polymorphisms associated with a decreased enzyme’s activity are *2 (681G>A) and *3 (636G>A). The variant *17 (-806 C>T) is associated with an increased enzyme’s activity.
[1] https://files.cpicpgx.org/data/guideline/publication/clopidogrel/2022/35034351.pdf
Format: 24 determinations
Storage: At -20°C. 8 freeze and thaw max.
Possible automation: Yes
Analysis software : Yes
Turn around time: Around 1 hour
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