Detection of TREC & KREC levels by Loop-mediated isothermal amplification



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The LAMP Human SCID detection KIT is an in vitro diagnostic KIT as primary screening method for the detection of SCID by Loop-mediated isothermal amplification (LAMP). This assay is dedicated to professional use in diagnostic laboratory. The device is not for self-testing.


Severe Combined Immunodeficiency Disease (SCID) is a condition in which there are no or abnormally low levels of T cells and/or low, high or normal numbers of B cells and NK cells. The prevalence is 1/50-100,000 newborns. In the absence of treatment, early signs of the disease begin to appear during the first few months of life and may include :

  • Growth retardation
  • Diarrhea
  • Frequent infections
    • Ear infections
    • Lung infections
    • Candidiasis
    • Infections that persist despite treatment
  • Pneumonia
  • Meningitis
  • Septicemia

Babies with SCID are protected by their mother's immune system for a short period of time after birth. Neonatal screening for SCID before symptoms appear makes it possible to perform a bone marrow transplant and thus save the newborn.

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