HLA-B57:01 (Not yet available)
Detection of the presence of HLA-B57:01 direct using a tag SNP by Loop-mediated isothermal amplification (KIT still in development and not yet available).
The LAMP Human HLA-B57 :01 Direct detection KIT is an in vitro diagnostic KIT for the detection of HLA-B57:01 alleles by Loop-mediated isothermal amplification (LAMP). This assay is dedicated to professional use in diagnostic laboratory. The device is not for self-testing.
The HLA-B*57:01 allele has been associated with hypersensitivity to abacavir, a highly effective nucleoside analog reverse-transcriptase inhibitor used to treat HIV infection and AIDS. Per the Clinical Pharmacogenomics Implementation Consortium (CPIC) dosing guidelines for abacavir and HLA-B, individuals who are positive for the HLA-B*57:01 allele are at an increased risk for abacavir hypersensitivity and it is not recommended for use in treating these individuals.
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