Sickle cell disorders encompass a wide range of genetic anomalies, including not only sickle cell anemia (homozygous HbSS), but also combination of HbS with other β-globin variants. Sickle cell disorders are clinically marked by the polymerization of HbS in red blood cells, leading to anemia, and acute and chronic tissue damage secondary to blood vessel occlusions. Hb disorders represent the most common single gene disorders in the world, with very high prevalence in some tropical and sub-tropical regions.
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